High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols

Kajsa Paulsson; Erik Forestier; Mette K. Andersen; Kirsi Autio; Gisela Barbany; Georg Borgström; Lucia Cavelier; Irina Golovleva; Sverre Heim; Kristiina Heinonen; Randi Hovland; Johann H. Johannsson; Eigil Kjeldsen; Ann Nordgren; Lars Palmqvist; Bertil Johansson

doi:10.3324/haematol.2013.085852

Haematologica (Sep 2013)

High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols

Kajsa Paulsson,
Erik Forestier,
Mette K. Andersen,
Kirsi Autio,
Gisela Barbany,
Georg Borgström,
Lucia Cavelier,
Irina Golovleva,
Sverre Heim,
Kristiina Heinonen,
Randi Hovland,
Johann H. Johannsson,
Eigil Kjeldsen,
Ann Nordgren,
Lars Palmqvist,
Bertil Johansson

Affiliations

Kajsa Paulsson: Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden
Erik Forestier: Department of Medical Biosciences, University of Umeå, Umeå, Sweden
Mette K. Andersen: The Cytogenetic Laboratory, The University Hospital Rigshospitalet, Copenhagen, Denmark
Kirsi Autio: Helsinki and Uusimaa Hospital Group, HUSLAB Laboratory of Genetics, Helsinki, Finland
Gisela Barbany: Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Georg Borgström: Helsinki and Uusimaa Hospital Group, HUSLAB Laboratory of Genetics, Helsinki, Finland
Lucia Cavelier: Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
Irina Golovleva: Department of Medical Biosciences, Medical and Clinical Genetics, University of Umeå, Umeå, Sweden
Sverre Heim: Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, and Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
Kristiina Heinonen: Genetic Laboratory, ISLAB, Kuopio, Finland
Randi Hovland: Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Helse-Bergen HF, Norway
Johann H. Johannsson: Department of Clinical Genetics and Cytogenetics, University Hospital, Reykjavik, Iceland
Eigil Kjeldsen: Cancer Cytogenetic Laboratory, Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
Ann Nordgren: Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Lars Palmqvist: Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
Bertil Johansson: Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden;Department of Clinical Genetics, University and Regional Laboratories Region Skåne, Lund, Sweden

DOI: https://doi.org/10.3324/haematol.2013.085852
Journal volume & issue: Vol. 98, no. 9

Abstract

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Between 1992 and 2008, 713 high hyperdiploid acute lymphoblastic leukemias in children aged 1–15 years were diagnosed and treated according to the Nordic Society for Pediatric Hematology and Oncology acute lymphoblastic leukemia 1992/2000 protocols. Twenty (2.8%) harbored t(1;19), t(9;22), der(11q23), or t(12;21). The median age of patients with “classic” high hyperdiploidy was lower than that of patients with translocation-positive high hyperdiploidy (P

Published in Haematologica

ISSN: 0390-6078 (Print); 1592-8721 (Online)
Publisher: Ferrata Storti Foundation
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://www.haematologica.org

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