Nature Communications (May 2018)
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype
- Sang Cheul Oh,
- Bo Hwa Sohn,
- Jae-Ho Cheong,
- Sang-Bae Kim,
- Jae Eun Lee,
- Ki Cheong Park,
- Sang Ho Lee,
- Jong-Lyul Park,
- Yun-Yong Park,
- Hyun-Sung Lee,
- Hee-Jin Jang,
- Eun Sung Park,
- Sang-Cheol Kim,
- Jeonghoon Heo,
- In-Sun Chu,
- You-Jin Jang,
- Young-Jae Mok,
- WonKyung Jung,
- Baek-Hui Kim,
- Aeree Kim,
- Jae Yong Cho,
- Jae Yun Lim,
- Yuki Hayashi,
- Shumei Song,
- Elena Elimova,
- Jeannelyn S. Estralla,
- Jeffrey H. Lee,
- Manoop S. Bhutani,
- Yiling Lu,
- Wenbin Liu,
- Jeeyun Lee,
- Won Ki Kang,
- Sung Kim,
- Sung Hoon Noh,
- Gordon B. Mills,
- Seon-Young Kim,
- Jaffer A. Ajani,
- Ju-Seog Lee
Affiliations
- Sang Cheul Oh
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Bo Hwa Sohn
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Jae-Ho Cheong
- Department of Surgery, Yonsei University College of Medicine
- Sang-Bae Kim
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Jae Eun Lee
- Department of Surgery, Yonsei University College of Medicine
- Ki Cheong Park
- Department of Surgery, Yonsei University College of Medicine
- Sang Ho Lee
- Department of Surgery, Kosin University, College of Medicine
- Jong-Lyul Park
- Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology
- Yun-Yong Park
- Department of Medicine, ASAN Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of Medicine
- Hyun-Sung Lee
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Hee-Jin Jang
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Eun Sung Park
- Medical Research Institute, College of Medicine, Inha University
- Sang-Cheol Kim
- Department of Biomedical Informatics, Center for Genome Science, National Institute of Health
- Jeonghoon Heo
- Department of Molecular Biology and Immunology, Kosin University, College of Medicine
- In-Sun Chu
- Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology
- You-Jin Jang
- Department of Surgery, Guro Hospital, College of Medicine, Korea University
- Young-Jae Mok
- Department of Surgery, Guro Hospital, College of Medicine, Korea University
- WonKyung Jung
- Department of Surgery, Guro Hospital, College of Medicine, Korea University
- Baek-Hui Kim
- Department of Pathology, Guro Hospital, College of Medicine, Korea University
- Aeree Kim
- Department of Pathology, Guro Hospital, College of Medicine, Korea University
- Jae Yong Cho
- Medical Oncology, Yonsei University College of Medicine
- Jae Yun Lim
- Medical Oncology, Yonsei University College of Medicine
- Yuki Hayashi
- Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
- Shumei Song
- Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
- Elena Elimova
- Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jeannelyn S. Estralla
- Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jeffrey H. Lee
- Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
- Manoop S. Bhutani
- Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
- Yiling Lu
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Wenbin Liu
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Jeeyun Lee
- Department of Medicine, Samsung Medical Center, Division of Hematology-Oncology
- Won Ki Kang
- Department of Medicine, Samsung Medical Center, Division of Hematology-Oncology
- Sung Kim
- Department of Surgery, Samsung Medical Center
- Sung Hoon Noh
- Department of Surgery, Yonsei University College of Medicine
- Gordon B. Mills
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Seon-Young Kim
- Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology
- Jaffer A. Ajani
- Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
- Ju-Seog Lee
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-04179-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
The prognosis and treatment of gastric cancer is complicated by heterogeneity. Here, the authors reveal two molecular subtypes, the mesenchymal subtype associated with poor survival and chemoresistance, and the epithelial phenotype associated with better survival and sensitivity to chemotherapy.
