Advances on reprogramming of fatty acid metabolism in pulmonary fibrosis

Abstract

Pulmonary fibrosis is a progressive interstitial fibrotic lung disease with high mortality. Its pathogenesis is complex and involves the reprogramming of fatty acid metabolism. This reprogramming includes changes in de novo fatty acid synthesis, uptake, oxidation, and derivatives. It crucially influences alveolar epithelial cell survival, macrophage polarization, and fibroblast activation, thereby playing a significant role in either exacerbating or mitigating the disease. Understanding and intervening in the reprogramming of fatty acid metabolism offers potential strategies for prevention, diagnosing and treatment of pulmonary fibrosis.

Keywords

• fatty acids|pulmonary fibrosis|metabolic reprogramming