The study of changes of serum sex hormones and 25-(OH)-D3 levels in postmenopausal patients with benign proxysmal positional vertigo

Abstract

Objective To explore the change of serum sex hormones and 25-hydroxycholecalciferol [25-(OH)-D3 ] level in postmenopausal female patients with benign paroxysmal positional vertigo (BPPV). Methods Electrochemiluminescence (ECL) assay was employed to detect the serum levels of estradiol (E2), progesterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), and 25-(OH)-D3 in 63 female postmenopausal BPPV patients with age 50-80 years from September 1, 2015 to February 1, 2017. Spearman rank correlation analysis was used to analyze the relation between age and E2 , E2 and 25-(OH)-D3. Univariate and multivariate stepwise Logistic regression analysis were used to screen the risk factors for BPPV. Results The serum levels of E2 [15.67 (10.96, 22.15) pg/ml] and 25-(OH)-D3 [(24.24 ± 1.05) ng/ml] in BPPV group were lower than those in control group [E2: 31.78 (25.60, 39.50) pg/ml, 25-(OH)-D3: (27.62 ± 0.76) ng/ml], and the differences were statistically significant (Z = -6.768, P = 0.000; t = -2.605, P = 0.010). There was no significant difference on progesterone, LH and FSH between 2 groups. Correlation analysis showed there was no relation between E2 and 25-(OH)-D3 levels in both groups. There was a negative correlation between age and E2 in control group (rs = -0.263, P = 0.038), but no correlation in BPPV group. Multivariate Logistic regression analysis showed decreased serum E2 and 25-(OH)-D3 levels maybe the risk factors for postmenopausal female BPPV patients. Conclusions E2 and 25-(OH)-D3 deficiency are independent risk factors for BPPV in postmenopausal female patients. DOI: 10.3969/j.issn.1672-6731.2019.01.007

Keywords

• Vertigo
• Otolithic membrane
• Calcifediol
• Gonadal steroid hormones
• Regression analysis