Dynamics of biochemical markers of systemic inflammatory response and renal functional condition in patients with myocardial infarction without ST-elevation in the dependence of the use of the blоcker of mineralocortycoіde receptors of eplerenone for the

Abstract

Aim. To estimate the dynamics of biochemical markers of myocardial damage and functional condition of the kidneys in patients with myocardial infarction without ST-elevation, depending on the use of the blocker of the mineralocorticoide receptors eplerenone for 3 and 6 months. Material and Methods. We examined 77 patients (63.6% of men) with myocardial infarction without ST-elevation from age 50 to 79 (mean 64.1±1.0) years. All patients on the 3rd day of hospitalization and during the 3rd and 6th months of the observation conducted a comprehensive assessment of the biochemical markers of myocardial damage and functional state of the kidneys. Results and Discussion. The evaluation of the dynamics of the humoral and metabolic condition of patients with myocardial infarction without ST-elevation indicated that the level of troponin I progressively decreased regardless of the use of eplerenone at the 6th month of observation compared with the original value. However, in the eplerenone group, the dynamics of the indicator for the 6th month was more significant, as well as a more significant decrease in the level of the indicator from the 3rd to the 6th month of treatment. A similar dynamics was observed with markers of systemic inflammation. Conclusions. The advantages of using eplerenone in patients with myocardial infarction without ST-elevation, which is characterized by a more significant decrease in the level of troponin I and markers of systemic inflammation during the 3rd and 6th months of treatment, have been obtained.

Keywords

• myocardial infarction without st-elevation, biochemical markers, renal function.