Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus

Abstract

Abstract Background Type 1 diabetes mellitus (T1DM) is a chronic inflammatory disease concerning insulin-producing β-cells destroyed by the conjoined action of auto reactive T cells, inflammatory cytokines and monocytic cells. Recent proof favors crucial role of cellular autoimmunity as well as its mediators in pathogenesis and following T1DM. We aimed to investigate whether IL-1α, IL-1β, or IL-10 an easily available inflammatory marker is associated with T1DM. Results The onset of T1DM was accompanied with elevation serum levels of IL-1α, IL-1β, and IL-10. ROC curve revealed that IL10 > 5.95 pg/ml predicted T1DM with sensitivity and specificity of 96% and 90%, respectively. Conclusion The raise of serum inflammatory cytokines such as IL-1α, IL-1β, and IL-10 of the patient may be exploited as potential markers for development of T1DM. The study proposes that level of inflammatory markers is upregulated in T1DM individual in an age-dependent manner and suggesting activation of the inflammatory immune response system.

Keywords

• Type 1 diabetes mellitus (T1DM)
• i Interleukin-1alpha (IL-1α)
• Interleukin-1beta (IL-1β)
• Interleukin-10 (IL-10)