Vіsnik Naukovih Doslіdžen' (Jan 2018)
STUDY OF THE HUMORAL COMPONENT OF IMMUNE SYSTEM IN CASES OF TRAUMATIC MANDIBULAR FRACTURES IN PATIENTS OF DIFFERENT PSYCHOSOMATIC TYPES OF PERSONALITY
Abstract
Immune system is crucial in the regulation of course of reparative processes in bone tissues and development of purulent complications. The correlation between the frequency of purulent complications and psychosomatic type of personality was established in recent studies. However, we have not found any publications on features of humoral disorders of immune system depending on the psychosomatic type of personality of patients with mandibular fractures. The aim of the study – to learn the functional disorders of immune system humoral component in patients with traumatic mandibular fractures depending on psychosomatic type of personality. Materials and Methods. 60 male patients diagnosed with traumatic unilateral open mandibular fractures in the area of a corner were divided into two groups according to the Eysenck’s classification: the group 1 – extraverts (36 individuals); the group 2 – introverts (24 individuals). Identification of T- and B-lymphocytes was performed by means of Status monoclonal antibodies. The quantity of subpopulations CD3+-, CD4+-, CD8+-, CD16+-lymphocytes was evaluated in percent. Venous blood was used as the material for immunological studies. The concentration of A, M, G immunoglobulins was estimated by Mancini method in dynamics on the 1st, 3rd, 7th days after the trauma. Results and Discussion. The increase in the number of CD22 + lymphocytes during the whole observation period in patients of both studied groups was established. IgG content in the first days after the trauma was increased in both studied groups, and on the 7th day, its content was normal only in patients of the group 1, in patients of the group 2 it was less than in the control group. Quantitative changes of IgA were of the same type in both studied groups: the increased level – on the first few days after the trauma, and by the 7th day of the study it was lower than the rates of the control group in the both studied groups that evidenced the depression of humoral component of immunity. The increase of IgM content in both studied groups during the whole observation period was the most pronounced during the early post-traumatic period. Conclusions. The results of the study proved insufficient functioning of humoral component of immune system that was manifested by the increased concentrations of all immunoglobulin classes, which were especially pronounced on the first days after the trauma. In the introvert patients quantitative changes in all immunoglobulin classes were more obvious.
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