RNA m6A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications

Chang Gu; Xin Shi; Chenyang Dai; Feng Shen; Gaetano Rocco; Jiafei Chen; Zhengyu Huang; Chunji Chen; Chuan He; Tao Huang; Chang Chen

The Innovation (Nov 2020)

RNA m6A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications

Chang Gu,
Xin Shi,
Chenyang Dai,
Feng Shen,
Gaetano Rocco,
Jiafei Chen,
Zhengyu Huang,
Chunji Chen,
Chuan He,
Tao Huang,
Chang Chen

Affiliations

Chang Gu: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
Xin Shi: Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China
Chenyang Dai: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
Feng Shen: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
Gaetano Rocco: Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Jiafei Chen: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
Zhengyu Huang: Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Chunji Chen: Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China
Chuan He: Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA; Medical Scientist Training Program/Committee on Cancer Biology, The University of Chicago, Chicago, IL, USA; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA; Corresponding author
Tao Huang: Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China; Corresponding author
Chang Chen: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China; Corresponding author

Journal volume & issue: Vol. 1, no. 3
p. 100066

Abstract

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N6-Methyladenosine (m6A) RNA modification brings a new dawn for RNA modification researches in recent years. This posttranscriptional RNA modification is dynamic and reversible, and is regulated by methylases (“writers”), demethylases (“erasers”), and proteins that preferentially recognize m6A modifications (“readers”). The change of RNA m6A modification regulates RNA metabolism in eucaryon, including translation, splicing, exporting, decay, and processing. Thereby the dysregulation of m6A may lead to tumorigenesis and progression. Given the tumorigenic role of abnormal m6A expression, m6A regulators may function as potential clinical therapeutic targets for cancers. In this review, we emphasize on the underlying mechanisms of m6A modifications in tumorigenesis and further introduce the potential m6A regulators-associated therapeutic targets for tumor therapy.

Published in The Innovation

ISSN: 2666-6758 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Science (General)
Website: https://www.cell.com/the-innovation

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