Structural basis of HIV-1 maturation inhibitor binding and activity

Sucharita Sarkar; Kaneil K. Zadrozny; Roman Zadorozhnyi; Ryan W. Russell; Caitlin M. Quinn; Alex Kleinpeter; Sherimay Ablan; Hamed Meshkin; Juan R. Perilla; Eric O. Freed; Barbie K. Ganser-Pornillos; Owen Pornillos; Angela M. Gronenborn; Tatyana Polenova

doi:10.1038/s41467-023-36569-y

Nature Communications (Mar 2023)

Structural basis of HIV-1 maturation inhibitor binding and activity

Sucharita Sarkar,
Kaneil K. Zadrozny,
Roman Zadorozhnyi,
Ryan W. Russell,
Caitlin M. Quinn,
Alex Kleinpeter,
Sherimay Ablan,
Hamed Meshkin,
Juan R. Perilla,
Eric O. Freed,
Barbie K. Ganser-Pornillos,
Owen Pornillos,
Angela M. Gronenborn,
Tatyana Polenova

Affiliations

Sucharita Sarkar: Department of Chemistry and Biochemistry, University of Delaware
Kaneil K. Zadrozny: Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine
Roman Zadorozhnyi: Department of Chemistry and Biochemistry, University of Delaware
Ryan W. Russell: Department of Chemistry and Biochemistry, University of Delaware
Caitlin M. Quinn: Department of Chemistry and Biochemistry, University of Delaware
Alex Kleinpeter: HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute
Sherimay Ablan: HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute
Hamed Meshkin: Department of Chemistry and Biochemistry, University of Delaware
Juan R. Perilla: Department of Chemistry and Biochemistry, University of Delaware
Eric O. Freed: HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute
Barbie K. Ganser-Pornillos: Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine
Owen Pornillos: Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine
Angela M. Gronenborn: Department of Chemistry and Biochemistry, University of Delaware
Tatyana Polenova: Department of Chemistry and Biochemistry, University of Delaware

DOI: https://doi.org/10.1038/s41467-023-36569-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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HIV maturation inhibitors such as bevirimat (BVM) interfering with Gag processing are emerging as alternative anti-retroviral drug candidates. Here, the authors report structures of assemblies of HIV-1 Gag fragments spanning the CA C-terminal domain and SP1 region bound to BVM.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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