Investigation of Niosomes for use as brucellosis vaccine

Abstract

Background: Niosomes are vesicles, a new drug delivery system, which can be It is used for sustained, controlled as well as targeted delivery of drugs. Niosomes are vesicles, a new drug delivery system, which can be They are used for sustained, controlled as well as targeted delivery of drugs and as vaccine candidates.Objectives: The aim of this study was to evaluate host response to niosomes containing chimeric protein as candidate for brucellosis vaccine.Methods: This study was experimentally designed in 2020 on 50 balb/c mice. These mice were randomly divided into different injection, oral and inhalation groups. Microbial strains were obtained from Razi Vaccine and Serum Institute. Microbial studies in the laboratory animal challenge test were prepared from the microbial collection of Pasteur Institute of Iran. Luria-Bertani liquid and solid culture medium prepared from Merck, Germany, Brucella agar culture medium (Gibco, USA) and Kanamycin antibiotic prepared from Roche, Germany were used in this study.Results: This study successfully announced that the niosomal form has better efficacy and better safety performance in Brucella vaccine design. The analysis of the results indicated the appropriate response of the immune system of laboratory mice, which can finally indicate the suitability of this immunogen structure in the design of a suitable vaccine against brucellosis.Conclusion: Niosomes are a drug delivery system that can be used as Controlled, sustained and targeted delivery of drugs like vaccines.

Keywords

• brucella
• chimeric protein
• vaccine