Fluids and Barriers of the CNS (Feb 2022)

k-Shape clustering for extracting macro-patterns in intracranial pressure signals

  • Isabel Martinez-Tejada,
  • Casper Schwartz Riedel,
  • Marianne Juhler,
  • Morten Andresen,
  • Jens E. Wilhjelm

DOI
https://doi.org/10.1186/s12987-022-00311-5
Journal volume & issue
Vol. 19, no. 1
pp. 1 – 13

Abstract

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Abstract Background Intracranial pressure (ICP) monitoring is a core component of neurosurgical diagnostics. With the introduction of telemetric monitoring devices in the last years, ICP monitoring has become feasible in a broader clinical setting including monitoring during full mobilization and at home, where a greater diversity of ICP waveforms are present. The need for identification of these variations, the so-called macro-patterns lasting seconds to minutes—emerges as a potential tool for better understanding the physiological underpinnings of patient symptoms. Methods We introduce a new methodology that serves as a foundation for future automatic macro-pattern identification in the ICP signal to comprehensively understand the appearance and distribution of these macro-patterns in the ICP signal and their clinical significance. Specifically, we describe an algorithm based on k-Shape clustering to build a standard library of such macro-patterns. Results In total, seven macro-patterns were extracted from the ICP signals. This macro-pattern library may be used as a basis for the classification of new ICP variation distributions based on clinical disease entities. Conclusions We provide the starting point for future researchers to use a computational approach to characterize ICP recordings from a wide cohort of disorders.

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