A specialized bone marrow microenvironment for fetal haematopoiesis

Yang Liu; Qi Chen; Hyun-Woo Jeong; Bong Ihn Koh; Emma C. Watson; Cong Xu; Martin Stehling; Bin Zhou; Ralf H. Adams

doi:10.1038/s41467-022-28775-x

Nature Communications (Mar 2022)

A specialized bone marrow microenvironment for fetal haematopoiesis

Yang Liu,
Qi Chen,
Hyun-Woo Jeong,
Bong Ihn Koh,
Emma C. Watson,
Cong Xu,
Martin Stehling,
Bin Zhou,
Ralf H. Adams

Affiliations

Yang Liu: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine
Qi Chen: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine
Hyun-Woo Jeong: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine
Bong Ihn Koh: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine
Emma C. Watson: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine
Cong Xu: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine
Martin Stehling: Flow Cytometry Unit, Max Planck Institute for Molecular Biomedicine
Bin Zhou: State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Ralf H. Adams: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine

DOI: https://doi.org/10.1038/s41467-022-28775-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The colonization of bone marrow by haematopoietic stem and progenitor cells is critical for lifelong blood cell formation. Here the authors report distinct features of fetal bone marrow and show that artery-derived signals promote haematopoietic colonization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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