Nature Communications (Feb 2021)

Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

  • Jang-June Park,
  • Emily P. Thi,
  • Victor H. Carpio,
  • Yingzhi Bi,
  • Andrew G. Cole,
  • Bruce D. Dorsey,
  • Kristi Fan,
  • Troy Harasym,
  • Christina L. Iott,
  • Salam Kadhim,
  • Jin Hyang Kim,
  • Amy C. H. Lee,
  • Duyan Nguyen,
  • Bhavna S. Paratala,
  • Ruiqing Qiu,
  • Andre White,
  • Damodharan Lakshminarasimhan,
  • Christopher Leo,
  • Robert K. Suto,
  • Rene Rijnbrand,
  • Sunny Tang,
  • Michael J. Sofia,
  • Chris B. Moore

DOI
https://doi.org/10.1038/s41467-021-21410-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Programmed death-ligand 1 (PD-L1) is involved in the inhibition of antigen specific T cells via ligation of programmed death 1 (PD-1). Here, the authors show checkpoint inhibition by use of small molecule inhibition of PD-L1 which in a humanised mouse model was shown to restore T cell responses and reduced tumour burden.