Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using
<i>in Silico</i>
Approach

Siaw Shi Boon; Chichao Xia; Maggie Haitian Wang; Ka Lai Yip; Ho Yin Luk; Sile Li; Rita W. Y. Ng; Christopher K. C. Lai; Paul Kay Sheung Chan; Zigui Chen

doi:10.1128/mBio.02687-21

mBio (Oct 2021)

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using <i>in Silico</i> Approach

Siaw Shi Boon,
Chichao Xia,
Maggie Haitian Wang,
Ka Lai Yip,
Ho Yin Luk,
Sile Li,
Rita W. Y. Ng,
Christopher K. C. Lai,
Paul Kay Sheung Chan,
Zigui Chen

Affiliations

Siaw Shi Boon: ORCiD; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Chichao Xia: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Maggie Haitian Wang: Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Ka Lai Yip: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Ho Yin Luk: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Sile Li: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Rita W. Y. Ng: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Christopher K. C. Lai: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Paul Kay Sheung Chan: ORCiD; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Zigui Chen: ORCiD; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China

DOI: https://doi.org/10.1128/mBio.02687-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Our study showed the global distribution of SARS-CoV-2 S protein variants from January 2020 to the end of April 2021. We highlighted the key amino acids of S protein subjected to positive selection.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal