Bladder cancer-associated microbiota: Recent advances and future perspectives

Wentao Zhang; Fuhan Yang; Shiyu Mao; Ruiliang Wang; Haotian Chen; Yuefei Ran; Shenghua Liu; Pengfei Wu; Yang Yan; Wei Li; Junfeng Zhang; Xudong Yao

Heliyon (Jan 2023)

Bladder cancer-associated microbiota: Recent advances and future perspectives

Wentao Zhang,
Fuhan Yang,
Shiyu Mao,
Ruiliang Wang,
Haotian Chen,
Yuefei Ran,
Shenghua Liu,
Pengfei Wu,
Yang Yan,
Wei Li,
Junfeng Zhang,
Xudong Yao

Affiliations

Wentao Zhang: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Fuhan Yang: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Shiyu Mao: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Ruiliang Wang: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Haotian Chen: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Yuefei Ran: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China; Shanghai Clinical College, Anhui Medical University, Hefei, China
Shenghua Liu: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Pengfei Wu: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Yang Yan: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Wei Li: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China; Corresponding author.Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China.
Junfeng Zhang: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China; Corresponding author.Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China.
Xudong Yao: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China; Corresponding author.Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China.

Journal volume & issue: Vol. 9, no. 1
p. e13012

Abstract

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Recent evidence suggests that the human genitourinary microbiome plays a significant role in mediating the development and progression of urological tumors, including bladder cancer (BC). Clinicians widely recognize the role of Bacille Calmette Guérin (BCG), an attenuated Mycobacterium tuberculosis vaccine, in the management of intermediate- and high-risk NMIBC. However, compared to the large body of evidence on the gut microbiota and gastrointestinal tumors, limited information is available about the interaction between BC and the genitourinary microbiome. This is an expanding field that merits further investigation. Urologists will need to consider the potential impact of the microbiome in BC diagnosis, prevention of recurrence and progression, and treatment prospects in the future. This review highlights the approaches adopted for microbiome research and the findings and inadequacies of current research on BC.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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