Advances of cerebral amyloid angiopathy and related cognitive impairment

Abstract

Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease(cSVD) in clinic. It is characterized by the deposition of amyloid β-protein (Aβ) in the cerebral vascular wall, including small and medium arteries of pia mater and cortex and medium and adventitia of capillaries, which can lead to cognitive impairment. Cerebral microbleeds(CMBs),white matter hyperintensity(WMH), enlarged perivascular space (EPVS) and cortical superficial siderosis are neuroimaging markers of it. At present, symptomatic treatment is the main method. Anticoagulation and antiplatelet therapy are still controversial.

Keywords

• Cerebral amyloid angiopathy; Cognition disorders; Review