The Flux of Phenolic Compounds through Silicone Membranes

Abstract

Phenols as a class of molecules have been reported to exhibit higher log maximum fluxes through human stratum corneum, SC, from water, log JMHAQ, than other classes of molecules. This suggests that their corresponding log maximum fluxes through silicone from water, log JMPAQ, may be useful to extend the existing n = 63 log JMPAQ database to include more log JMPAQ values greater than 0.0. The log JMPAQ values for n = 7 phenols predicted to give log JMPAQ values greater than 0.0 based on their log JMHAQ values have been experimentally determined. These n = 7 new log JMPAQ values have been added to the existing n = 63 log JMPAQ database to give a new n = 70 database and the n = 7 literature log JMHAQ values have been added to the existing n = 48 log JMHAQ database (matched to the n = 63 log JMPAQ database) to give a new n = 55 database. The addition of the n = 7 phenols improved the correlations of these flux databases when fitted to the Roberts-Sloan equation, RS, as well as the correlation between the matched experimental (Exp.) log JMPAQ with the Exp. log JMHAQ.

Keywords

• maximum flux
• silicone membrane
• Roberts–Sloan equation
• water solubility
• lipid solubility
• human skin in vitro