Nature Communications (Sep 2017)
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis
- Zhiping Liu,
- Siyuan Yan,
- Jiaojiao Wang,
- Yiming Xu,
- Yong Wang,
- Shuya Zhang,
- Xizhen Xu,
- Qiuhua Yang,
- Xianqiu Zeng,
- Yaqi Zhou,
- Xuejiao Gu,
- Sarah Lu,
- Zhongjie Fu,
- David J. Fulton,
- Neal L. Weintraub,
- Ruth B. Caldwell,
- Wenbo Zhang,
- Chaodong Wu,
- Xiao-Ling Liu,
- Jiang-Fan Chen,
- Aftab Ahmad,
- Ismail Kaddour-Djebbar,
- Mohamed Al-Shabrawey,
- Qinkai Li,
- Xuejun Jiang,
- Ye Sun,
- Akrit Sodhi,
- Lois Smith,
- Mei Hong,
- Yuqing Huo
Affiliations
- Zhiping Liu
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Siyuan Yan
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Jiaojiao Wang
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Yiming Xu
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Yong Wang
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Shuya Zhang
- Molecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University
- Xizhen Xu
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Qiuhua Yang
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Xianqiu Zeng
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Yaqi Zhou
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Xuejiao Gu
- Molecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University
- Sarah Lu
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Zhongjie Fu
- Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School
- David J. Fulton
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Neal L. Weintraub
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Ruth B. Caldwell
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Wenbo Zhang
- Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch (UTMB)
- Chaodong Wu
- Department of Nutrition and Food Science, Texas A&M University
- Xiao-Ling Liu
- Molecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University
- Jiang-Fan Chen
- Molecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University
- Aftab Ahmad
- Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham
- Ismail Kaddour-Djebbar
- Department of Physiology, Medical College of Georgia, Augusta University
- Mohamed Al-Shabrawey
- James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University
- Qinkai Li
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Xuejun Jiang
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Science
- Ye Sun
- Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School
- Akrit Sodhi
- Wilmer Eye Institute, Johns Hopkins School of Medicine
- Lois Smith
- Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School
- Mei Hong
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Yuqing Huo
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- DOI
- https://doi.org/10.1038/s41467-017-00551-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new therapeutic targets for disease treatment.
