Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries

Abstract

Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-molecule libraries.

Keywords

• natural products
• indole
• small-molecule library
• diversity-oriented synthesis
• complexity-to-diversity (Ctd) strategy
• biomimetic synthesis