Cells (Aug 2019)

Closer to Nature Through Dynamic Culture Systems

  • Tzyy-Yue Wong,
  • Sheng-Nan Chang,
  • Rong-Chang Jhong,
  • Ching-Jiunn Tseng,
  • Gwo-Ching Sun,
  • Pei-Wen Cheng

DOI
https://doi.org/10.3390/cells8090942
Journal volume & issue
Vol. 8, no. 9
p. 942

Abstract

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Mechanics in the human body are required for normal cell function at a molecular level. It is now clear that mechanical stimulations play significant roles in cell growth, differentiation, and migration in normal and diseased cells. Recent studies have led to the discovery that normal and cancer cells have different mechanosensing properties. Here, we discuss the application and the physiological and pathological meaning of mechanical stimulations. To reveal the optimal conditions for mimicking an in vivo microenvironment, we must, therefore, discern the mechanotransduction occurring in cells.

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