Nature Communications (Jul 2019)

Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses

  • Karl E. Bauer,
  • Inmaculada Segura,
  • Imre Gaspar,
  • Volker Scheuss,
  • Christin Illig,
  • Georg Ammer,
  • Saskia Hutten,
  • Eugénia Basyuk,
  • Sandra M. Fernández-Moya,
  • Janina Ehses,
  • Edouard Bertrand,
  • Michael A. Kiebler

DOI
https://doi.org/10.1038/s41467-019-11123-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Asymmetric subcellular mRNA distribution is important for local translation of neuronal mRNAs. Here the authors employed MS2 live-cell imaging and showed that the reporter mRNA containing the 3’ UTR of Rgs4 shows an anterograde transport bias, dependent on neuronal activity and the protein Staufen2, and mediates sustained mRNA recruitment to synapses.