Plasma miR-126 expression correlates with risk and severity of psoriasis and its high level at baseline predicts worse response to Tripterygium wilfordii Hook F in combination with acitretin

Yanjuan Duan; Jialing Zou; Jingyi Mao; Dongjie Guo; Minfeng Wu; Ning Xu; Jie Zhou; Yanbin Zhang; Wanjun Guo; Waishu Jin

Biomedicine & Pharmacotherapy (Jul 2019)

Plasma miR-126 expression correlates with risk and severity of psoriasis and its high level at baseline predicts worse response to Tripterygium wilfordii Hook F in combination with acitretin

Yanjuan Duan,
Jialing Zou,
Jingyi Mao,
Dongjie Guo,
Minfeng Wu,
Ning Xu,
Jie Zhou,
Yanbin Zhang,
Wanjun Guo,
Waishu Jin

Affiliations

Yanjuan Duan: Department of Dermatology, Seventh People’s Hospital of Shanghai University of TCM, Shanghai, China
Jialing Zou: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jingyi Mao: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Dongjie Guo: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Minfeng Wu: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Ning Xu: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jie Zhou: Department of Dermatology, Seventh People’s Hospital of Shanghai University of TCM, Shanghai, China
Yanbin Zhang: Department of Dermatology, Seventh People’s Hospital of Shanghai University of TCM, Shanghai, China
Wanjun Guo: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Waishu Jin: Department of Dermatology, The Yantai Yuhuangding Hospital of Qingdao University, Yantai, China; Corresponding author at: Department of Dermatology, The Yantai Yuhuangding Hospital of Qingdao University, 20 Yudong Road, Yantai, 264000, China.

Journal volume & issue: Vol. 115

Abstract

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Background: Treatment of psoriasis is always difficult, which requires intensive scientific research. Objective: Tripterygium wilfordii Hook F (TwHF) with acitretin(TwHF + acitretin) is normally used in treating psoriasis. This study aimed to investigate the correlation of plasma miR-126 expression with risk and severity of psoriasis, and its predictive value of response to TwHF + acitretin treatment in psoriasis. Methods: MiRNA-126(MiR-126) expression in plasma was analyzed in psoriasis patients at month 0 (M0), M1, M3 and M6 and in health controls (HCs) at enrollment by qPCR. Psoriasis-affected body surface area (BSA) and Psoriasis Area and Severity Index (PASI) score were used to assess severity and treatment response. Results: Plasma miR-126 levels were decreased in psoriasis patients compared with HCs (P 0.05). Conclusion: Plasma miR-126 expression is negatively correlated with psoriasis risk and severity, and its high baseline level can be used as a biomarker to predict worse clinical response to TwHF + acitretin treatment in psoriasis.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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