Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å

Jonathan A. Flores; Bassam G. Haddad; Kimberly A. Dolan; Janette B. Myers; Craig C. Yoshioka; Jeremy Copperman; Daniel M. Zuckerman; Steve L. Reichow

doi:10.1038/s41467-020-18120-5

Nature Communications (Aug 2020)

Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å

Jonathan A. Flores,
Bassam G. Haddad,
Kimberly A. Dolan,
Janette B. Myers,
Craig C. Yoshioka,
Jeremy Copperman,
Daniel M. Zuckerman,
Steve L. Reichow

Affiliations

Jonathan A. Flores: Department of Chemical Physiology and Biochemistry, Oregon Health and Science University
Bassam G. Haddad: Department of Chemistry, Portland State University
Kimberly A. Dolan: Department of Chemistry, Portland State University
Janette B. Myers: Department of Chemistry, Portland State University
Craig C. Yoshioka: Department of Biomedical Engineering, Oregon Health and Science University
Jeremy Copperman: Department of Biomedical Engineering, Oregon Health and Science University
Daniel M. Zuckerman: Department of Biomedical Engineering, Oregon Health and Science University
Steve L. Reichow: Department of Chemical Physiology and Biochemistry, Oregon Health and Science University

DOI: https://doi.org/10.1038/s41467-020-18120-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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The local lipid environment is known to affect the structure, stability and intercellular channel activity of gap junctions, however, the molecular basis for these effects remains unknown. Here authors report the CryoEM structure of Cx46/50 lipid-embedded channels, by which they reveal a lipid-induced stabilization to the channel.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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