Materials Research Express (Jan 2020)

Fabrication and characterization of wound dressings containing gentamicin/silver for wounds in diabetes mellitus patients

  • Xinyu Bie,
  • Muhammad Qamar Khan,
  • Azeem Ullah,
  • Sana Ullah,
  • Davood Kharaghani,
  • Duy-Nam Phan,
  • Yasushi Tamada,
  • Ick Soo Kim

DOI
https://doi.org/10.1088/2053-1591/ab8337
Journal volume & issue
Vol. 7, no. 4
p. 045004

Abstract

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In this study, the dual functional wound dressings for diabetic patients were fabricated with the help of gentamicin/ cellulose acetate by electrospinning. The resultant nanofibers were functionalized with silver nanoparticles (AgNPs) on its surface by a simple facile wetting process. Herein, gentamicin (Ge) was used for the objective to heal the infection inflammation and Ag NPs were loaded for the antibacterial properties. The resultant CA/Ge/Ag nanofibers were characterized for morphology analysis, chemical interactions examination, release behavior, structure analysis and antibacterial efficiency by scan electron microscope/ transmission electron microscope, FTIR/XPS, ICP study, XRD study and disc diffusion method of antibacterial, respectively. Based on characterization results it was concluded that all samples of CA/Ge/Ag nanofibers showed the antibacterial properties and appreciable release behavior.

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