Ascendancy of nanoparticles coated vaccines and their role in future of vaccinology

Abstract

Nanoparticles have emerged as a promising platform for the delivery of vaccines due to their unique properties, such as their small size, high surface area, and tunable surface properties. Coating these nanoparticles with antigens and adjuvants enhances their stability, immunogenicity, and targeting ability, thereby leading to improved vaccine efficacy. Vaccines have revolutionized the field of immunization, providing effective protection against numerous bacterial infections. This review paper expl ores the diverse strategies employed by vaccines to stimulate a robust immune response and confer immunity. Various vaccine types, including inactivated toxins (toxoids), live bacterial vaccines, live attenuated vaccines, and virus -like particles (VLPs), are investigated in terms of their mechanisms and suitability for different populations. While live bacterial vaccines and live attenuated vaccines have demonstrated efficacy, caution must be exercised when administering them to individuals with compromised immune systems. As an alternative, VLPs have emerged as a promising non-infectious option that closely resembles viral structures. VLPs offer advantages in terms of safety, cost-effectiveness, and their ability to elicit targeted immune responses, this could lead to significant breakthroughs in vaccine development. Ongoing research is dedicated to the development of vaccines targeting specific pathogens and combating antimicrobial resistance (AMR). Innovative approaches include mRNA-based vaccines, vaccines designed to target surface polysaccharides, vaccines that induce helper T cell responses, and vaccines against specific virulence factors. By understanding the mechanisms and potential applications of different vaccine types, researchers and healthcare professionals can contribute to the continued progress in immunization and protect individuals and communities from the burden of infectious diseases.