Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes

Takuya Tada; Belinda M. Dcosta; Marie I. Samanovic; Ramin S. Herati; Amber Cornelius; Hao Zhou; Ada Vaill; Wes Kazmierski; Mark J. Mulligan; Nathaniel R. Landau

doi:10.1128/mBio.00696-21

mBio (Jun 2021)

Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes

Takuya Tada,
Belinda M. Dcosta,
Marie I. Samanovic,
Ramin S. Herati,
Amber Cornelius,
Hao Zhou,
Ada Vaill,
Wes Kazmierski,
Mark J. Mulligan,
Nathaniel R. Landau

Affiliations

Takuya Tada: Department of Microbiology, NYU Grossman School of Medicine, New York, New York, USA
Belinda M. Dcosta: Department of Microbiology, NYU Grossman School of Medicine, New York, New York, USA
Marie I. Samanovic: NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, New York, USA
Ramin S. Herati: NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, New York, USA
Amber Cornelius: NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, New York, USA
Hao Zhou: Department of Microbiology, NYU Grossman School of Medicine, New York, New York, USA
Ada Vaill: Biohaven Pharmaceuticals, Inc., New Haven, Connecticut, USA
Wes Kazmierski: Biohaven Pharmaceuticals, Inc., New Haven, Connecticut, USA
Mark J. Mulligan: NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, New York, USA
Nathaniel R. Landau: ORCiD; Department of Microbiology, NYU Grossman School of Medicine, New York, New York, USA

DOI: https://doi.org/10.1128/mBio.00696-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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The rapid evolution of SARS-CoV-2 variants has raised concerns with regard to their potential to escape from vaccine-elicited antibodies and anti-spike protein monoclonal antibodies. We report here on an analysis of sera from recovered patients and vaccinated individuals and on neutralization by Regeneron therapeutic monoclonal antibodies.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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