A chitosan-based hydrogel sealant with effective closure for sutureless dural

Guangyu Ying; Wen Fang; Hanhai Zeng; Hongwen Ding; Huaijun Chen; Zhiqi Jiang; Lili Chen; Qiaoling Hu; Yongjian Zhu; Gao Chen

Materials & Design (Mar 2023)

A chitosan-based hydrogel sealant with effective closure for sutureless dural

Guangyu Ying,
Wen Fang,
Hanhai Zeng,
Hongwen Ding,
Huaijun Chen,
Zhiqi Jiang,
Lili Chen,
Qiaoling Hu,
Yongjian Zhu,
Gao Chen

Affiliations

Guangyu Ying: Department of Neurological Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China
Wen Fang: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China
Hanhai Zeng: Department of Neurological Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China
Hongwen Ding: Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Huaijun Chen: Department of Neurological Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China
Zhiqi Jiang: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China
Lili Chen: Department of Neurology, Xiasha Campus, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China
Qiaoling Hu: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China; Corresponding authors at: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China (Q.H.). Department of Neurological Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.Z.; G.C.).
Yongjian Zhu: Department of Neurological Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China; Corresponding authors at: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China (Q.H.). Department of Neurological Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.Z.; G.C.).
Gao Chen: Department of Neurological Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China; Corresponding authors at: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China (Q.H.). Department of Neurological Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.Z.; G.C.).

Journal volume & issue: Vol. 227
p. 111730

Abstract

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Dural defects and subsequent leakage of cerebrospinal fluid (CSF) after neurosurgery are often associated with serious complications or even death. The associated surgical suture or sealant repair is often followed by pinhole leakage or a loose seal. Thus, pressure-resistant, high-viscosity dural repair is highly desired. In this study, a chitosan-based hydrogel sealant with the benefits of easy handling, high safety, rapid setting time, simple injection, excellent mechanical strength, and strong tissue adhesiveness was created to accomplish efficient sutureless dural closure during operation. This sealant may successfully prevent or stop intraoperative CSF leaking and provide sutureless dural closure. In conclusion, this sutureless chitosan-based hydrogel sealant could be a very promising candidate with high practical value for dural repair.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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