Андрология и генитальная хирургия (Mar 2016)

An influence of androgen receptor (AR) gene СAG-polymorphism on spermatogenesis in infertile men

  • V. B. Chernykh,
  • S. A. Rudneva,
  • T. M. Sorokina,
  • L. V. Shileyko,
  • T. V. Ostroumova,
  • S. A. Ermolaeva,
  • L. F. Kurilo,
  • O. P. Ryzhkova,
  • E. A. Bliznets,
  • A. L. Chukhrova,
  • A. V. Polyakov

DOI
https://doi.org/10.17650/2070-9781-2015-16-4-55-61
Journal volume & issue
Vol. 16, no. 4
pp. 55 – 61

Abstract

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We analyzed the results of semen examination in 200 infertile men with various numbers of GAG-repeats in the exon 1 of the androgen receptor (AR) gene. The number of repeats ranged from 7 to 31, the average number of repeats was 22.2 ± 1.6, with the most common variant (13 %) present 21 repeats. Our findings confirm that of AR gene СAG-polymorphism can an effect on sperm parameters and male fertility. The spermatogenesis can be impaired in infertile men with “short” CAG-repeats not less than with “long” CAG-repeats.

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