Interactions between anthocyanins and gut microbiota in promoting healthy aging

Abstract

Aging is a natural and inevitable physiological process that poses a serious threat to physical health, leading to age-related diseases and placing a heavy burden on the public health system. This study explores intervention measures to promote healthy aging and prolong lifespan. Anthocyanins (ACNs), as a class of flavonoids widely presented in fruits, vegetables and grains, exhibit strong antioxidant and anti-inflammatory activities. Recent studies indicate that ACNs exert health effects primarily by interacting with gut microbiota. Here, we introduced the digestion and absorption of ACNs, and mainly elaborated on the role of ACNs in delaying aging through gut microbiota. In addition, we described the changes in gut microbiota mediated by ACNs and their impact on age-related chronic diseases, including cardiovascular diseases, neurodegenerative diseases, cancer, and sarcopenia. Therefore, ACNs have a broad application prospect in the development of functional foods with anti-aging effects by regulating gut microbiota.

Keywords

• Anthocyanins
• Gut microbiota
• Cyanidin-3-O-glucoside
• Healthy aging
• Age-related disease
• Microbiota-gut-brain axis