Nature Communications (May 2022)
Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant
- Fanglei Zuo,
- Hassan Abolhassani,
- Likun Du,
- Antonio Piralla,
- Federico Bertoglio,
- Leire de Campos-Mata,
- Hui Wan,
- Maren Schubert,
- Irene Cassaniti,
- Yating Wang,
- Josè Camilla Sammartino,
- Rui Sun,
- Stelios Vlachiotis,
- Federica Bergami,
- Makiko Kumagai-Braesch,
- Juni Andréll,
- Zhaoxia Zhang,
- Yintong Xue,
- Esther Veronika Wenzel,
- Luigi Calzolai,
- Luca Varani,
- Nima Rezaei,
- Zahra Chavoshzadeh,
- Fausto Baldanti,
- Michael Hust,
- Lennart Hammarström,
- Harold Marcotte,
- Qiang Pan-Hammarström
Affiliations
- Fanglei Zuo
- Department of Biosciences and Nutrition, Karolinska Institutet
- Hassan Abolhassani
- Department of Biosciences and Nutrition, Karolinska Institutet
- Likun Du
- Department of Biosciences and Nutrition, Karolinska Institutet
- Antonio Piralla
- Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo
- Federico Bertoglio
- Department of Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig
- Leire de Campos-Mata
- Department of Biosciences and Nutrition, Karolinska Institutet
- Hui Wan
- Department of Biosciences and Nutrition, Karolinska Institutet
- Maren Schubert
- Department of Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig
- Irene Cassaniti
- Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo
- Yating Wang
- Department of Biosciences and Nutrition, Karolinska Institutet
- Josè Camilla Sammartino
- Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo
- Rui Sun
- Department of Biosciences and Nutrition, Karolinska Institutet
- Stelios Vlachiotis
- Department of Biosciences and Nutrition, Karolinska Institutet
- Federica Bergami
- Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo
- Makiko Kumagai-Braesch
- Division of Transplantation Surgery, CLINTEC, Karolinska Institutet at Karolinska University Hospital
- Juni Andréll
- Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
- Zhaoxia Zhang
- Department of Aging Neurology orthopedics, Karolinska University Hospital Huddinge
- Yintong Xue
- Department of Immunology, Peking University Health Science Center
- Esther Veronika Wenzel
- Department of Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig
- Luigi Calzolai
- European Commission, Joint Research Centre
- Luca Varani
- Institute for Research in Biomedicine, Università della Svizzera italiana (USI)
- Nima Rezaei
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- Zahra Chavoshzadeh
- Pediatric Infections Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences
- Fausto Baldanti
- Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo
- Michael Hust
- Department of Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig
- Lennart Hammarström
- Department of Biosciences and Nutrition, Karolinska Institutet
- Harold Marcotte
- Department of Biosciences and Nutrition, Karolinska Institutet
- Qiang Pan-Hammarström
- Department of Biosciences and Nutrition, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-022-30340-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 8
Abstract
Emerging SARS-CoV-2 variants of concern (VOCs) raises concerns regarding vaccine efficacy. Here, the authors evaluate the neutralizing antibody, and cellular response elicited following inactivated vaccine immunization, and mRNA booster, against the Omicron variant.
