Nature Communications (Sep 2016)
Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
- Wei Deng,
- Yan Xu,
- Wenchun Chen,
- David S. Paul,
- Anum K. Syed,
- Matthew A. Dragovich,
- Xin Liang,
- Philip Zakas,
- Michael C. Berndt,
- Jorge Di Paola,
- Jerry Ware,
- Francois Lanza,
- Christopher B. Doering,
- Wolfgang Bergmeier,
- X. Frank Zhang,
- Renhao Li
Affiliations
- Wei Deng
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine
- Yan Xu
- Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University
- Wenchun Chen
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine
- David S. Paul
- McAllister Heart Institute, University of North Carolina
- Anum K. Syed
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine
- Matthew A. Dragovich
- Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University
- Xin Liang
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine
- Philip Zakas
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine
- Michael C. Berndt
- Faculty of Health Sciences, Curtin University
- Jorge Di Paola
- Department of Pediatrics and Human Genetics, Genomics Program, University of Colorado School of Medicine
- Jerry Ware
- Department of Physiology and Biophysics, University of Arkansas for Medical Sciences
- Francois Lanza
- UMR_S949 INSERM, Université de Strasbourg, EFS-Alsace
- Christopher B. Doering
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine
- Wolfgang Bergmeier
- McAllister Heart Institute, University of North Carolina
- X. Frank Zhang
- Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University
- Renhao Li
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms12863
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, leading to platelets clearance.
