The molecular dynamics of subdistal appendages in multi-ciliated cells

Hyunchul Ryu; Haeryung Lee; Jiyeon Lee; Hyuna Noh; Miram Shin; Vijay Kumar; Sejeong Hong; Jaebong Kim; Soochul Park

doi:10.1038/s41467-021-20902-4

Nature Communications (Jan 2021)

The molecular dynamics of subdistal appendages in multi-ciliated cells

Hyunchul Ryu,
Haeryung Lee,
Jiyeon Lee,
Hyuna Noh,
Miram Shin,
Vijay Kumar,
Sejeong Hong,
Jaebong Kim,
Soochul Park

Affiliations

Hyunchul Ryu: Department of Biological Sciences, Sookmyung Women’s University
Haeryung Lee: Department of Biological Sciences, Sookmyung Women’s University
Jiyeon Lee: Department of Biological Sciences, Sookmyung Women’s University
Hyuna Noh: Department of Biological Sciences, Sookmyung Women’s University
Miram Shin: Department of Biological Sciences, Sookmyung Women’s University
Vijay Kumar: Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University
Sejeong Hong: Department of Biological Sciences, Sookmyung Women’s University
Jaebong Kim: Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University
Soochul Park: Department of Biological Sciences, Sookmyung Women’s University

DOI: https://doi.org/10.1038/s41467-021-20902-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Cilia originate from a basal body and basal foot, but the precise molecular mechanisms of basal foot biogenesis are unclear. Here, the authors show that ANKS1A interacts with FOP to transform the subdistal appendages from an unpolarized structure to a polarized structure with a basal foot.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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