The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response

Bo Liu; Jiancheng Huang; Amina Ashraf; Oindrila Rahaman; Jing Lou; Ling Wang; Peiliang Cai; Jinping Wen; Shoaib Anwaar; Xiaoli Liu; Hai Ni; Dipyaman Ganguly; Jijun Zhao; Cliff Y. Yang

doi:10.1038/s41467-021-24352-w

Nature Communications (Jul 2021)

The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response

Bo Liu,
Jiancheng Huang,
Amina Ashraf,
Oindrila Rahaman,
Jing Lou,
Ling Wang,
Peiliang Cai,
Jinping Wen,
Shoaib Anwaar,
Xiaoli Liu,
Hai Ni,
Dipyaman Ganguly,
Jijun Zhao,
Cliff Y. Yang

Affiliations

Bo Liu: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Jiancheng Huang: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Amina Ashraf: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Oindrila Rahaman: IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology
Jing Lou: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Ling Wang: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Peiliang Cai: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Jinping Wen: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Shoaib Anwaar: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Xiaoli Liu: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Hai Ni: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou
Dipyaman Ganguly: IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology
Jijun Zhao: Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen University
Cliff Y. Yang: Department of Immunology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou

DOI: https://doi.org/10.1038/s41467-021-24352-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Zinc finger proteins are involved in the resolution of immune responses and function by degrading mRNA of inflammatory cytokines. Here the authors show MCPIP3 promotes skin inflammation via modification of cytokine profiles in pDCs and macrophages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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