Nature Communications (Jan 2019)

Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit

  • Kosei Sato,
  • Hiroki Ito,
  • Atsushi Yokoyama,
  • Gakuta Toba,
  • Daisuke Yamamoto

DOI
https://doi.org/10.1038/s41467-018-08146-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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It is unclear how some Drosophila neurons develop sex-specific neurites that contribute to dimorphic circuitries required for gendered behavior. The authors show that sex-specific cleavage by the E3 ubiquitin ligase Cullin1 and 26S proteasome of the pleiotropic BTB-ZF transcription factor Lola confers its sexual fate-inducing ability in these neurons.