MRI-guided robotic arm drives optogenetic fMRI with concurrent Ca2+ recording

Yi Chen; Patricia Pais-Roldan; Xuming Chen; Michael H. Frosz; Xin Yu

doi:10.1038/s41467-019-10450-3

Nature Communications (Jun 2019)

MRI-guided robotic arm drives optogenetic fMRI with concurrent Ca2+ recording

Yi Chen,
Patricia Pais-Roldan,
Xuming Chen,
Michael H. Frosz,
Xin Yu

Affiliations

Yi Chen: Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics
Patricia Pais-Roldan: Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics
Xuming Chen: Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics
Michael H. Frosz: Max Planck Institute for the Science of Light
Xin Yu: Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics

DOI: https://doi.org/10.1038/s41467-019-10450-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Fiber optic implantation in deep areas of the rodent’s brain for MRI combined with optogenetics is challenging. Here the authors use an MRI-guided robotic arm as the navigation method for accurate fiber optic placement and precise microinjection during multi-modal fMRI, optogenetics and calcium recordings.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal