Effects of Intermittent Teriparatide Administration on Bone Graft Healing and Local Simvastatin

Abstract

Introduction: Improving bone healing by various methods is one of the research areas of oral and maxillofacial surgery, as in the surgical branches dealing with hard tissue in medicine. Many methods, such as bone grafts, drugs, hormones, and tissue engineering applications, are used in bone reconstruction and rehabilitation. Moreover, improving bone healing is critical for better surgical outcomes. This study aimed to compare early and late period effects of intermittent teriparatide application on bone graft and local simvastatin application from histopathological, histomorphometric analysis, and biochemical aspects. Materials and Methods: 24 New Zealand rabbits were divided into four groups. While experimental groups received intermittent teriparatide (30µg/kg), control groups were given sterile distilled water. A total of 3 defects were created on each rabbit’s right and left tibia. Bone graft and local simvastatin were randomly applied to the opened defects, and one defect was left blank for control purposes. Rabbits were sacrificed on days 15 and 30 to examine early and late bone healing. Blood was drawn for biochemical analysis. Results: The healing score and new bone development in teriparatide applied and grafted defects were statistically significant compared to all groups (p0.05). Conclusion: Better bone healing and bone graft healing in rabbits treated with teriparatide may encourage improved surgical outcomes in clinical practice. Keywords: Teriparatide; Intermittent; Bone healing; Bone graft; Simvastatin.

Keywords

• Teriparatide; Intermittent; Bone healing; Bone graft; Simvastatin.