Clinical Significance and Risk Factors of Local Recurrence in Synovial Sarcoma: A Retrospective Analysis of 171 Cases

Hongqiang Zhang; Wending Huang; Wending Huang; Qi Feng; Wei Sun; Wei Sun; Wangjun Yan; Wangjun Yan; Chunmeng Wang; Chunmeng Wang; Jianing Zhang; Kai Huang; Lin Yu; Lin Yu; Xinglong Qu; Yong Chen; Yong Chen

doi:10.3389/fsurg.2021.736146

Frontiers in Surgery (Jan 2022)

Clinical Significance and Risk Factors of Local Recurrence in Synovial Sarcoma: A Retrospective Analysis of 171 Cases

Hongqiang Zhang,
Wending Huang,
Wending Huang,
Qi Feng,
Wei Sun,
Wei Sun,
Wangjun Yan,
Wangjun Yan,
Chunmeng Wang,
Chunmeng Wang,
Jianing Zhang,
Kai Huang,
Lin Yu,
Lin Yu,
Xinglong Qu,
Yong Chen,
Yong Chen

Affiliations

Hongqiang Zhang: Department of Surgical Oncology, Shanghai Cancer Center Minhang Branch Hospital, Fudan University, Shanghai, China
Wending Huang: Department of Musculoskeletal Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China
Wending Huang: Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China
Qi Feng: Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Wei Sun: Department of Musculoskeletal Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China
Wei Sun: Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China
Wangjun Yan: Department of Musculoskeletal Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China
Wangjun Yan: Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China
Chunmeng Wang: Department of Musculoskeletal Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China
Chunmeng Wang: Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China
Jianing Zhang: Department of Surgery Base, Shanghai Cancer Center, Fudan University, Shanghai, China
Kai Huang: Department of Surgery, Brandon Regional Hospital, Morsani College of Medicine, Hospital Corporation of America Healthcare/University of South Florida Health, Tampa, FL, United States
Lin Yu: Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China
Lin Yu: Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, China
Xinglong Qu: Department of Surgical Oncology, Shanghai Cancer Center Minhang Branch Hospital, Fudan University, Shanghai, China
Yong Chen: Department of Musculoskeletal Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China
Yong Chen: Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China

DOI: https://doi.org/10.3389/fsurg.2021.736146
Journal volume & issue: Vol. 8

Abstract

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Objective: To investigate risk factors of local recurrence of synovial sarcoma and the impact of local recurrence on survival.Methods: We retrospectively reviewed clinical data of patients with II to IIIB (AJCC8) synovial sarcoma who underwent surgery at our center between March 2005 and December 2016. Data relating clinicopathological factors, treatment and prognosis were collected. The impact of local recurrence on overall survival (OS), local recurrence-free survival (LRFS), and distant relapse-free survival (DRFS) were analyzed. The prognostic factors associated with local recurrence were also analyzed using Kaplan-Meier Curves and Cox regression analysis.Results: A total of 171 patients were included in this analysis. After a median follow-up of 48 months, 66 patients (38.6%) experienced local recurrence. The 5-year OS, LRFS, and DRFS rates of patients with local recurrence were 37.6, 6.1, and 24.1%, respectively. Multivariate analysis showed that larger initial tumors, multiple recurrences, positive resection margins, marginal resection, and lack of adjuvant therapy were associated with higher local recurrence.Conclusion: Local recurrence of synovial sarcoma is associated with distant metastasis and poor survival. Chemoradiation improves the prognosis of patients with local recurrence, in particular those for which recurrence occurs shortly after initial treatment.

Published in Frontiers in Surgery

ISSN: 2296-875X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Surgery
Website: https://www.frontiersin.org/journals/surgery

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