Heart Failure With Reduced Ejection Fraction in a Patient With Erdheim-Chester Disease on Dabrafenib

Santiago Saenz-Ancira, MD; Javier Higuera-Ornelas, MD; Breno Bernades-Souza, MD; Ryan Severdija, MD; Maria Jose Santa Ana-Bayona, MS; Maria Silvana Salazar, MD; Moises A. Vazquez, MD; Jose Antonio Luna-Alvarez, MD

JACC: Case Reports (Jun 2024)

Heart Failure With Reduced Ejection Fraction in a Patient With Erdheim-Chester Disease on Dabrafenib

Santiago Saenz-Ancira, MD,
Javier Higuera-Ornelas, MD,
Breno Bernades-Souza, MD,
Ryan Severdija, MD,
Maria Jose Santa Ana-Bayona, MS,
Maria Silvana Salazar, MD,
Moises A. Vazquez, MD,
Jose Antonio Luna-Alvarez, MD

Affiliations

Santiago Saenz-Ancira, MD: Mexican Faculty of Medicine, La Salle University, Mexico City, Mexico; Address for correspondence: Dr Santiago Saenz-Ancira, Mexican Faculty of Medicine, La Salle University, Isla 32, Ampliación Alpes, Alvaro Obregón, Mexico City 01710, Mexico.
Javier Higuera-Ornelas, MD: Mexican Faculty of Medicine, La Salle University, Mexico City, Mexico
Breno Bernades-Souza, MD: Internal Medicine Department, Jackson Memorial Hospital, University of Miami, Miami, Florida, USA
Ryan Severdija, MD: Internal Medicine Department, Jackson Memorial Hospital, University of Miami, Miami, Florida, USA
Maria Jose Santa Ana-Bayona, MS: Mexican Faculty of Medicine, La Salle University, Mexico City, Mexico
Maria Silvana Salazar, MD: Internal Medicine Department, Jackson Memorial Hospital, University of Miami, Miami, Florida, USA
Moises A. Vazquez, MD: Internal Medicine Department, Jackson Memorial Hospital, University of Miami, Miami, Florida, USA
Jose Antonio Luna-Alvarez, MD: Internal Medicine Department, Jackson Memorial Hospital, University of Miami, Miami, Florida, USA

Journal volume & issue: Vol. 29, no. 12
p. 102374

Abstract

Read online

A 54-year-old woman with a diagnosis of Erdheim-Chester disease under therapy with dabrafenib presents with clinical signs of heart failure. After discontinuing the offending medication and initiating guideline-directed medical therapy for heart failure with reduced ejection fraction, the clinical picture improved.

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

About the journal

Abstract

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