From genetics to systems biology of stress-related mental disorders

Shareefa Dalvie; Chris Chatzinakos; Obada Al Zoubi; Foivos Georgiadis; Lee Lancashire; Nikolaos P. Daskalakis

Neurobiology of Stress (Nov 2021)

From genetics to systems biology of stress-related mental disorders

Shareefa Dalvie,
Chris Chatzinakos,
Obada Al Zoubi,
Foivos Georgiadis,
Lee Lancashire,
Nikolaos P. Daskalakis

Affiliations

Shareefa Dalvie: South African Medical Research Council (SAMRC), Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa; South African Medical Research Council (SAMRC), Unit on Child & Adolescent Health, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa; Corresponding author. South African Medical Research Council (SAMRC), Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Chris Chatzinakos: Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, USA
Obada Al Zoubi: Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, USA
Foivos Georgiadis: Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, USA
Lee Lancashire: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, USA; Department of Data Science, Cohen Veterans Bioscience, New York, USA
Nikolaos P. Daskalakis: Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, USA; Corresponding author. Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, USA.

Journal volume & issue: Vol. 15
p. 100393

Abstract

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Many individuals will be exposed to some form of traumatic stress in their lifetime which, in turn, increases the likelihood of developing stress-related disorders such as post-traumatic stress disorder (PTSD), major depressive disorder (MDD) and anxiety disorders (ANX). The development of these disorders is also influenced by genetics and have heritability estimates ranging between ∼30 and 70%. In this review, we provide an overview of the findings of genome-wide association studies for PTSD, depression and ANX, and we observe a clear genetic overlap between these three diagnostic categories. We go on to highlight the results from transcriptomic and epigenomic studies, and, given the multifactorial nature of stress-related disorders, we provide an overview of the gene-environment studies that have been conducted to date. Finally, we discuss systems biology approaches that are now seeing wider utility in determining a more holistic view of these complex disorders.

Published in Neurobiology of Stress

ISSN: 2352-2895 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system; Science: Physiology: Neurophysiology and neuropsychology
Website: http://www.journals.elsevier.com/neurobiology-of-stress/

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Abstract

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