Ru(II) photocages enable precise control over enzyme activity with red light

Dmytro Havrylyuk; Austin C. Hachey; Alexander Fenton; David K. Heidary; Edith C. Glazer

doi:10.1038/s41467-022-31269-5

Nature Communications (Jun 2022)

Ru(II) photocages enable precise control over enzyme activity with red light

Dmytro Havrylyuk,
Austin C. Hachey,
Alexander Fenton,
David K. Heidary,
Edith C. Glazer

Affiliations

Dmytro Havrylyuk: Department of Chemistry, University of Kentucky
Austin C. Hachey: Department of Chemistry, University of Kentucky
Alexander Fenton: Department of Chemistry, University of Kentucky
David K. Heidary: Department of Chemistry, University of Kentucky
Edith C. Glazer: Department of Chemistry, University of Kentucky

DOI: https://doi.org/10.1038/s41467-022-31269-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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The cytochrome P450 enzyme CYP1B1 is overexpressed in a variety of tumors, and is correlated with poor treatment outcomes; thus, it is desirable to develop CYP1B1 inhibitors to restore chemotherapy efficacy. Here the authors describe the creation of light-triggered CYP1B1 inhibitors as “prodrugs”, and achieve >6000-fold improvement in potency upon activation with low-energy (660 nm) light.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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