A Case Report of Early-Onset Alzheimer’s Disease Using ¹⁸F-FDG PET and ¹⁸F-FBB PET

Abstract

We describe a 40-year-old female patient who presented with sleep disturbance, intermittent headache, and gradual subjective cognitive decline. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) showed mild FDG hypometabolism in bilateral parietal and temporal lobes. However, 18F-florbetaben (FBB) amyloid PET revealed diffuse amyloid retention in the lateral temporal cortex, frontal cortex, posterior cingulate cortex/precuneus, parietal cortex, and cerebellum. This finding supports the clinical significance of amyloid imaging in diagnostic work-up of early-onset Alzheimer’s disease (EOAD).

Keywords

• early-onset Alzheimer’s disease
• ¹⁸F-FDG PET
• ¹⁸F-florbetaben PET
• case report