Antitumor Effect of Bevacizumab in a Xenograft Model of Canine Hemangiopericytoma

Masaki Michishita; Tatsuya Uto; Ryota Nakazawa; Hisashi Yoshimura; Kikumi Ogihara; Yuko Naya; Tsuyoshi Tajima; Daigo Azakami; Seigo Kishikawa; Toshiro Arai; Kimimasa Takahashi

Journal of Pharmacological Sciences (Jan 2013)

Antitumor Effect of Bevacizumab in a Xenograft Model of Canine Hemangiopericytoma

Masaki Michishita,
Tatsuya Uto,
Ryota Nakazawa,
Hisashi Yoshimura,
Kikumi Ogihara,
Yuko Naya,
Tsuyoshi Tajima,
Daigo Azakami,
Seigo Kishikawa,
Toshiro Arai,
Kimimasa Takahashi

Affiliations

Masaki Michishita: Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan; Corresponding author. [email protected]
Tatsuya Uto: Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
Ryota Nakazawa: Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
Hisashi Yoshimura: Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
Kikumi Ogihara: Department of Pathology, School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan
Yuko Naya: Department of Pathology, School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan
Tsuyoshi Tajima: Department of Veterinary Pharmacology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
Daigo Azakami: Department of Veterinary Nursing, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
Seigo Kishikawa: Department of Pathology, School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan
Toshiro Arai: Department of Veterinary Biochemistry, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
Kimimasa Takahashi: Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan

Journal volume & issue: Vol. 121, no. 4
pp. 339 – 342

Abstract

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Abstract.: Canine hemangiopericytoma (CHP) is characterized by frequent local recurrence and increased invasiveness. Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis in tumors. The aim of the present study was to investigate the effect of a single dose of bevacizumab on a xenograft model of CHP. VEGF protein was secreted from cultured CHP cells and interacted with bevacizumab. Bevacizumab treatment suppressed tumor growth by inhibiting tumor angiogenesis, whereas no significant differences were observed in the proliferation index and apoptosis rates of treated and untreated mice. Thus, bevacizumab had antitumor effects in a xenograft model of CHP. Keywords:: bevacizumab, canine hemangiopericytoma, vascular endothelial growth factor (VEGF)

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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