Catalytic asymmetric C–Si bond activation via torsional strain-promoted Rh-catalyzed aryl-Narasaka acylation

Jia Feng; Xiufen Bi; Xiaoping Xue; Na Li; Lei Shi; Zhenhua Gu

doi:10.1038/s41467-020-18273-3

Nature Communications (Sep 2020)

Catalytic asymmetric C–Si bond activation via torsional strain-promoted Rh-catalyzed aryl-Narasaka acylation

Jia Feng,
Xiufen Bi,
Xiaoping Xue,
Na Li,
Lei Shi,
Zhenhua Gu

Affiliations

Jia Feng: Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China
Xiufen Bi: Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China
Xiaoping Xue: Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China
Na Li: Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China
Lei Shi: Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China
Zhenhua Gu: Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-020-18273-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Methods to access atropisomers bearing silanol groups are of value in organic synthesis. Here, the authors report a rhodium-catalyzed torsional strain-promoted asymmetric ring-opening reaction for the synthesis of α-silyl biaryl atropisomers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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