Nature Communications (Nov 2021)
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
- Jialiang S. Wang,
- Tushar Kamath,
- Courtney M. Mazur,
- Fatemeh Mirzamohammadi,
- Daniel Rotter,
- Hironori Hojo,
- Christian D. Castro,
- Nicha Tokavanich,
- Rushi Patel,
- Nicolas Govea,
- Tetsuya Enishi,
- Yunshu Wu,
- Janaina da Silva Martins,
- Michael Bruce,
- Daniel J. Brooks,
- Mary L. Bouxsein,
- Danielle Tokarz,
- Charles P. Lin,
- Abdul Abdul,
- Evan Z. Macosko,
- Melissa Fiscaletti,
- Craig F. Munns,
- Pearl Ryder,
- Maria Kost-Alimova,
- Patrick Byrne,
- Beth Cimini,
- Makoto Fujiwara,
- Henry M. Kronenberg,
- Marc N. Wein
Affiliations
- Jialiang S. Wang
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Tushar Kamath
- Broad Institute of Harvard and MIT
- Courtney M. Mazur
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Fatemeh Mirzamohammadi
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Daniel Rotter
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Hironori Hojo
- Center for Disease Biology and Integrative Medicine, The University of Tokyo Graduate School of Medicine
- Christian D. Castro
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Nicha Tokavanich
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Rushi Patel
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Nicolas Govea
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Tetsuya Enishi
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Yunshu Wu
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Janaina da Silva Martins
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Michael Bruce
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Daniel J. Brooks
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Mary L. Bouxsein
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Danielle Tokarz
- Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
- Charles P. Lin
- Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
- Abdul Abdul
- Broad Institute of Harvard and MIT
- Evan Z. Macosko
- Broad Institute of Harvard and MIT
- Melissa Fiscaletti
- Pediatric Department, Sainte-Justine University Hospital Centre
- Craig F. Munns
- Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead
- Pearl Ryder
- Broad Institute of Harvard and MIT
- Maria Kost-Alimova
- Broad Institute of Harvard and MIT
- Patrick Byrne
- Broad Institute of Harvard and MIT
- Beth Cimini
- Broad Institute of Harvard and MIT
- Makoto Fujiwara
- Department of Pediatrics, Osaka University Graduate School of Medicine
- Henry M. Kronenberg
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Marc N. Wein
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-021-26571-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
The molecular circuitry that drives dendrite formation during osteocytogenesis remains poorly understood. Here the authors show that deletion of Sp7, a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes severe defects in osteocyte dendrites.
