Effects of l-tryptophan on gastric emptying evaluated by breath test in relation to gastric accommodation evaluated by Barostat in rats

Abstract

Gastric emptying has been known to correlate the pyloric sphincter contractile function and distention-induced gastric relaxation (gastric accommodation). In the present study, the effects of l-tryptophan on the gastric emptying and accommodation were evaluated by breath test using [1-13C]acetic acid and Barostat study, respectively, in rats. l-Tryptophan significantly decreased Cmax and AUC120min and delayed Tmax, indicating the inhibition of gastric emptying. l-Tryptophan significantly enhanced the gastric accommodation. These findings show that l-tryptophan may inhibit the gastric emptying through the enhanced gastric accommodation. Therefore, l-tryptophan may be useful for the therapy of postprandial dyspepsia, especially for early satiety.

Keywords

• l-Tryptophan
• Gastric emptying
• Gastric accommodation in rat