Nature Communications (Apr 2022)

Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage

  • Enrica Boda,
  • Martina Lorenzati,
  • Roberta Parolisi,
  • Brian Harding,
  • Gianmarco Pallavicini,
  • Luca Bonfanti,
  • Amanda Moccia,
  • Stephanie Bielas,
  • Ferdinando Di Cunto,
  • Annalisa Buffo

DOI
https://doi.org/10.1038/s41467-022-30010-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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Here the authors show that, depending on their distinct developmental origins and ability to counteract oxidative stress, dorsal and ventral oligodendrocyte progenitor cells of the postnatal mouse brain are differentially vulnerable to DNA damage.