Determination of Serum D-Dimer Levels in Breast Cancer Patients Referred to Imam Sajjad Hospital in Ramsarin 2016

Abstract

Introduction Breast cancer is one of the most common cancers among women and is spreading with the highest rate in developing countries. The aim of this study was to evaluate serum levels of D-dimer in patients with breast cancer. Materials and Methods : In this cross-sectional study, 100 the patients with the diagnosis of breast cancer who have been admitted at Imam Sajjad Hospital for further treatment were enrolled. Results The average serum D-dimer in stage IV was 628±304, in stage III was 229±101 and in stage II was 180±29. In addition, the frequency of abnormal D-dimer was higher in patients at stage IV. The D-dimer level and the frequency of abnormal D-dimer level were higher in patients with lymph node involvement. Moreover, patients who had abnormal CEA and CA15-3 tumor markers had higher D-dimer level. We have also found serum D-dimer levels in patients 41-50 years old group was higher than other groups. Conclusion In general, increase in serum D-dimer levels are associated with advanced disease stage, lymph node involvement, and worse prognosis and since the D-dimer is a safe, inexpensive, and available marker can be used to assess prognosis of disease and survival of the patients

Keywords

• breast cancer
• D-dimer
• prognosis of disease
• Ramsar