Crystals (Jun 2021)
Effect of Batchelor Flow on Polymorphic Crystallization in a Rotating Disk Crystallizer
Abstract
In this work, the influence of Batchelor flow on the polymorphic crystallization in a rotating disk (RD) crystallizer was investigated. By regulating crystallization parameters, i.e., the rotation speed, cooling rate, and ethanol fraction, we found that a higher fraction of L-histidine stable Form-A at the induction time and a faster rate of phase transformation could be obtained in the RD crystallizer as compared to previous results in a mixing tank crystallizer. Based on these results, we concluded that the polymorphic crystallization in the RD crystallizer was more effective due to Batchelor flow fluid motion.
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