Follow-Up Study of Children with Mixed Rotavirus Infection

Abstract

Introduction. Rotavirus infection is an actual problem of practical health care and the leading cause of viral diarrhea in children of early age [1]. Rotavirus infection in infants may occur as a combined form, and the leading place often belongs to opportunistic flora [4]. Objective: to study the clinical and laboratory features and catamnesis in children with acute mixed rotavirus infection. Materials and methods. The study involved 31 patients aged 1 to 34 months, with the assessment: of anamnestic information about the disease, clinical status, laboratory and immunological data of the research, the therapy. It was retrospective case-control study. Analysis of the results has been carried out using the application package Statistica 6.0 StatSoft Inc. Results. According to the bacteriological study, in 31 (22.1 %) children with rotavirus infection we isolated opportunistic microorganisms. All children had intoxication syndrome in the form of apathy, loss or lack of appetite, fever. At the time of children hospitalization, lesions of the digestive system was characterized by vomiting, diarrhea, flatulence, rumbling and equivalents, typical for pain in the abdomen, in the form of anxiety and crying. At mixed form of rotavirus infection, in all cases we observed the lesions of the small intestine, which is often combined with lesions of the stomach, less often — of the large intestine. The severity of the lesions of gastrointestinal tract was also evaluated during stool test analysis. Follow-up monitoring is conducted to determine the main complaints of patients and duration of rotavirus persistence during convalescence in children with acute mixed rotavirus infection. Clinical supervision was carried out within three months after the onset of the disease. Determination of rotavirus antigen in coprofiltrates was performed by enzyme-linked immunosorbent assay on day 14, as well as in 1, 2 and 3 months from the onset. Conclusions. 1. In the mixed form of rotavirus infection, in all cases we observed the lesions of the small intestine, which is often combined with lesions of the stomach, less often — of the large intestine. 2. Follow-up of children who suffered a mixed rotavirus infection should be carried out within three months, as in this period there are both common complaints and complaints from the gastrointestinal tract, not only in children in whom rotavirus antigen is still detectable, but also in children without isolation of rotavirus antigen.

Keywords

• children
• rotavirus infection
• mixed variant
• clinical picture
• catamnesis