Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation

Irving L. M. H. Aye; Sungsam Gong; Giulia Avellino; Roberta Barbagallo; Francesca Gaccioli; Benjamin J. Jenkins; Albert Koulman; Andrew J. Murray; D. Stephen Charnock-Jones; Gordon C. S. Smith

doi:10.1038/s42003-022-03530-6

Communications Biology (Jun 2022)

Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation

Irving L. M. H. Aye,
Sungsam Gong,
Giulia Avellino,
Roberta Barbagallo,
Francesca Gaccioli,
Benjamin J. Jenkins,
Albert Koulman,
Andrew J. Murray,
D. Stephen Charnock-Jones,
Gordon C. S. Smith

Affiliations

Irving L. M. H. Aye: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Sungsam Gong: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Giulia Avellino: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Roberta Barbagallo: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Francesca Gaccioli: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Benjamin J. Jenkins: NIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge
Albert Koulman: NIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge
Andrew J. Murray: Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge
D. Stephen Charnock-Jones: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Gordon C. S. Smith: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre

DOI: https://doi.org/10.1038/s42003-022-03530-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Sex-dependent metabolism of spermine alter trophoblast gene expression through acetyl-coA biosynthesis and histone acetylation, indicating that escape of spermine synthase from X-linked inactivation partially contributes to placental sex differences.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal